The National Instruments PCI-6281 Multifunction Data Acquisition (DAQ) device (Part Number: 779019-01) is part of the M Series, designed to deliver enhanced performance with 18-bit analog input accuracy. This device encompasses a voltage range of ±10 V and achieves a resolution equivalent to 5 digits for direct current measurements. Equipped with a built-in low-pass filter, the PCI-6281 effectively mitigates high-frequency noise while operating at an adjustable frequency of up to 40 kHz, preventing aliasing for precise data acquisition. With 16 single-ended or 8 differential analog input channels, each capable of sampling at 625 kS/s, this DAQ also features two 16-bit analog output channels and two counter/timers with a 32-bit resolution operating at 80 MHz. Digital I/O capabilities include 24 lines and seven programmable input ranges. The PCI-6281 is compatible with SCC or SCXI signal conditioning modules, making it versatile for research, design testing applications, laboratory automation, and manufacturing tests. This device operates utilizing the NI-DAQmx driver software, integrating seamlessly with software development environments such as LabVIEW, LabWindows/CVI, or Measurement Studio. Furthermore, it can be verified using the Measurement & Automation Explorer (MAX) tool. The PCI-6281 requires a warm-up time of 15 minutes and should be calibrated at least every two years for optimal performance. With a robust design, it features one 68-pin VHDCI I/O connector and supports a maximum operating voltage of 11 V. The device’s physical dimensions are 4.2 x 6.1 inches, and it weighs approximately 5.6 oz. It operates effectively within a temperature range of 0 ºC to 55 ºC and can be stored between -20 ºC and 70 ºC, with a humidity tolerance of 10% RH to 90% RH. The PCI-6281 has vibration ratings of 0.3 grms during operation and 2.4 grms for non-operating conditions within a frequency range of 5 to 500 Hz. While the PCI-6281 is no longer sold directly by National Instruments, it remains available through Apex Waves for purchase and repairs.